95% of the good microbes in your body are in your gut. When in balance, these tiny organisms work together with your body to support many important systems, such as your immune system. In fact, 70-80% of your immune cells are in your gut! The tiny ecosystem of microbes in your stomach and intestines is known as your “gut microbiome”.
A problem occurs when the good microbes are overpowered by bad microbes. This creates a state of imbalance known as “gut dysbiosis”. Since your gut microbiome is so essential to the proper functioning of many of your body’s systems, gut dysbiosis is linked to various diseases- even brain diseases- such as:
Type 2 diabetes
Inflammatory bowel disease
Alzheimer’s disease
Parkinson’s disease
Amyotrophic lateral sclerosis
What affects your gut microbiota? Stress, alcohol, certain foods, the use of antibiotics can all harm the good microbes in your gut, leading to gut dysbiosis. Gut dysbiosis can also cause inflammation, which can lead to what we call “leaky gut”.
The lining of your intestines is important for keeping most material inside your gut, while also letting things like water and nutrients be absorbed through it. In order to let certain things through the barrier, your intestine lining has to be somewhat permeable by having gaps between cells. However, when the gaps become too big due to inflammation, bigger particles can seep through. This is how leaky gut starts.
Food particles that escape your intestinal lining cause more inflammation. This is why leaky gut can is linked to inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
The backbone of our immune system lies in our gut. When we have gut dysbiosis, leaky gut, and inflammation, our immune system can become dysregulated. This leads to a loss of tolerance for certain foods, environmental substances such as chemicals, and eventually our own cells.
3 Red Flags for Leaky Gut
Food sensitivities
Environmental sensitivities
Autoimmune disease
Healing Leaky Gut With Functional Medicine
As a functional medicine office, our focus is to dig deeper and address chronic health concerns by getting to the root cause. Because leaky gut is often the root cause of most inflammatory disorders and autoimmune diseases, our care is very gut-focused.
One of the most common questions asked in the natural health community is, “How do I fix my gut?” The problem is that this is not exactly a one-size-fits-all situation! Our personalized plans are designed to find and remove your specific triggers, which are not the same for everyone.
Probiotics
Since gut dysbiosis is a factor contributing to leaky gut, it is beneficial to add healthy bacteria back into the gut to “take up parking spots” and out-compete bad bacteria. Dr. Ian Hollaman uses advanced GI testing to identify exactly which strains of probiotics will be most beneficial for each patient.
Sometimes, before adding in good bacteria, the gut needs to be cleared of an infection, or overgrowth, of bad bacteria. Small intestine bacterial overgrowth (SIBO) is a difficult monster to tackle, but we have successfully helped many of our patients get it under control.
Prebiotics
Eating a fiber-rich diet gives the good bacteria in your gut plenty of good food! This is another way to help their populations grow.
Polyphenols
Polyphenols are antioxidants that help reduce stress on your body’s cells, therefore reducing inflammation. A recent study found that eating a polyphenol-rich diet for 8 weeks helped change the gut microbiota and therefore reduced intestinal permeability (aka leaky gut). This study used polyphenols from cocoa and green tea.
Dr. Ian’s proprietary supplement ImmunoXym contains caffeine-free green tea extract for its polyphenol content along with a specially formulated blend of probiotics and a slew of other vitamins essential for your immune system to regulate itself.
Glutamine
Glutamine supplementation has been shown to dramatically and safely reduce symptoms in IBS patients that have leaky gut.
The Dr. Autoimmune Difference
At Dr. Autoimmune, we use a functional medicine approach to address the root cause of leaky gut and all other gut issues. Our solutions are always natural, always personalized, and always backed by science. If you are ready to change your life, click the “Start Your Journey” button at the bottom of this page!
Juvenile idiopathic arthritis (JIA), formerly known as juvenile rheumatoid arthritis (RA), is joint inflammation in children 16 years of age or younger, lasting for at least 6 weeks. Unlike adult rheumatoid arthritis (RA) that is chronic and can last a lifetime without proper diagnosis or intervention, children usually outgrow JIA. But do they really?
JIA is…drum roll please…an autoimmune disease. Children with predisposed genes, such as a part of a gene called HLA antigen DR4, could be at a higher risk for developing JIA. Even if the symptoms of JIA subside, the risk of developing an autoimmune condition later in life is probable. All autoimmune conditions can be connected to “leaky gut”, a problem where the gut barrier breaks down and inflammation begins to trigger an autoimmune response. Even if your child does not have gut-related symptoms, it is quite common that those with JIA have small intestinal bacterial overgrowth, undergrowth, or other infectious bugs that must be brought under control with proper evaluation and support.
There is evidence that early exposure to antibiotics and compromised gut health could be contributing factors. Additional studies support the connection between JIA, type 1 diabetes, food allergies, and inflammatory bowel disease (IBS). Infants who were born vaginally vs. by c-section tend to have more Bifidobacterium in their gut, which is associated with a strong immune response. Nursed infants also have higher levels of this same beneficial bacteria in addition to Lactobacilli and Streptococci. Bottle-fed infants could be lacking these healthy bacteria, and may be at increased risk of developing an autoimmune disease.
Systemic onset JIA affects one or more joints, combined with high fever and a skin rash. It may also cause inflammation of internal organs, including the heart, liver, spleen, and lymph nodes. It is the least common type. It affects 1 in 10 to about 1 in 7 children with JIA.
Oligoarticular JIA affects 1 to 4 joints in the first 6 months of disease. If no more joints are affected after 6 months, this type is called persistent. If more joints are affected after 6 months, it is called extended.
Polyarticular JIA affects 5 or more joints in the first 6 months of disease. Blood tests for rheumatoid factor (RF) will show if this type is RF-positive or RF-negative.
Enthesitis-related JIA is arthritis and swelling of the tissue where bone meets a tendon or ligament. It often affects the hips, knees, and feet.
Psoriatic arthritis may have both arthritis and a red, scaly skin disease called psoriasis. 2 or more of the following symptoms may be present:
Inflammation of a finger or toe
Pits or ridges in fingernails
A first-degree relative with psoriasis
Undifferentiated arthritis is arthritis that has symptoms of 2 or more JIA types above. Or the symptoms might not match any type of JIA.
How do you know if your child may have JIA? A physical exam may not be enough to determine a clear diagnosis. A MRI or X-ray could show the degree of inflammation, and a comprehensive blood panel may show the presence of the substance’s antinuclear antibody (ANA) and rheumatoid factor. These tests can help rule out other diseases. As well, the most significant and accurate marker for rheumatoid arthritis, cyclic citrullinated peptides (CCP) should be run.
Functional medicine excels at this aspect of determining the root cause and how to rehab the immune system. If you suspect your child may have juvenile idiopathic arthritis, Dr. Autoimmune can help. Click the “Start Your Journey” button at the bottom of this page or call today to schedule a new patient evaluation with Dr. Ian Hollaman: 303-882-8447, press 0 to speak with Felice.
Eating healthy isn’t always enough. We can eat a variety of organic vegetables, fruits, and meats and still be missing out on the macronutrients that these foods deliver. Poor soil health from overcropping leads to less nutrient-dense foods, and our internal gut health may be missing the “good stuff” that helps us absorb and digest these “healthy” food sources.
Your digestive juices include hydrochloric acid (HCL), several enzymes, and a mucus coating that protects the lining of your stomach. Hydrochloric acid helps your body to break down, digest, and absorb nutrients such as protein. It also eliminates bacteria and viruses in the stomach, protecting your body from infection.
Hypochlorhydria is the state of having low stomach acid. This condition can be caused by consuming poor quality, highly processed foods, alcohol or smoking. Normal aging can also be a contributor to decreased hydrochloric acid. For those with hypochlorhydria, supplementing may be the answer to finding the balance for your metabolic system. Taking medications that suppress the symptoms of acid reflux (a symptom of hypochlorhydria) have been shown to contribute to leaky gut. Chronic gastrointestinal complaints are often addressed with medications that often make the bark worse than the bite.
How do you know if you are digesting and absorbing those organic foods that you so carefully cultivate or purchase?
If you have many of the symptoms above, and suspect you may not be utilizing your nutrients effectively, try taking the HCL Challenge described in this link. The basic concept is to take one HCL pill with each meal on day one, 2 with each meal on day 2, 3 with each meal on day 3 and so on. When you reach heartburn within 5 minutes after taking the dose, that will be the point where you want to back off by one pill each meal until you can dismiss the heartburn. Remember that we are all bio-individual and may react differently, so please consult your practitioner if you have any questions or concerns.
HCL-XYM to the Rescue
HCL-XYM is a blend of betaine hydrochloride (HCL) and the three most effective plant-based digestive enzymes: protease, amylase and lipase, in a base of trace minerals. All Dr. Autoimmune clients take HCL-XYM prior to every meal in order to:
help support the body’s natural ability to produce HCL
offer relief from occasional gas, bloating and indigestion
support digestion and absorption
create the proper pH in which protein digestion enzymes work
help to extract vitamin B12 from food
maintain healthy intestinal flora levels
If you suffer from many of these symptoms, HCL-XYM could help support your digestion. Call Dr. Autoimmune to discuss options on how we can get to the root cause of your symptoms at 303-882-8447.
For the month of July, we will be offering HCL-XYM at 15% off retail in office purchases only. Or, you can order online here, enter one-time access code USE777, and use code IAN10 at checkout for 10% off.
See what Dr. Autoimmune suggests eating to support your gut and immune health here.
Learn about the link between ticks, Lyme disease and autoimmune disease and how to protect yourself from this dangerous trio.
These itty bitty bugs climb out as cold weather fades. Particularly in woody, adventure-seeking communities like Colorado, people take to the outdoors (and so do the ticks!).
Ticks are No Treat
Ticks are tiny insects that attach themselves to the skin of animals and humans. Lyme disease is a bacterial infection that is transmitted to humans through the bite of an infected tick. The symptoms of Lyme disease can vary, but they often include”:
Fever
Headache
Fatigue
A distinctive rash known as erythema migrans
If Lyme disease is not treated, it can spread to the joints, heart, and nervous system. In some cases, Lyme disease can lead to an autoimmune condition. Autoimmunity occurs when the body’s immune system mistakenly attacks healthy tissues. This can occur in people with Lyme disease if the bacteria spreads to the liver and triggers an autoimmune response. In severe cases, autoimmunity can cause organ damage and even death. Lyme disease is a serious condition that requires prompt treatment. Ticks can also carry other diseases, including Rocky Mountain spotted fever and babesiosis (Lyme co-infection), but Lyme disease is the most common tick-borne infection in North America.
There are more than 80 different types of autoimmune diseases, and they affect people of all ages. Lyme disease is a serious health problem and can lead to autoimmunity, but there are steps you can take to protect yourself from ticks and other insects that carry the disease. You should wear long pants and sleeves when you are outdoors in areas where ticks live. You should also use natural insect repellent (made with essential oils) on your skin and clothing. Be sure to check yourself and your pets for ticks after spending time outdoors, and remove any that are found promptly.
It’s often very difficult to diagnose a Lyme infection. Many people live with undiagnosed symptoms for years before getting to the root cause. Lyme disease is best detected by a blood test, which looks for antibodies to the Lyme bacteria. The test can be performed using either a whole blood sample or a serum sample. Antibodies to Lyme disease are typically produced within 3-6 weeks of infection, so it is best to wait at least 6 weeks after possible exposure before getting tested. It’s important to get proper testing as not all tests are created equal. Lyme disease can also be detected using a urine test, but this is not as accurate as the blood test. Lyme disease is a serious infection that can cause a wide range of symptoms, so it is important to get tested if you think you may have been exposed to the bacteria.
All Testing is Not Created Equal
It is important to use the proper type of testing for Lyme. Polymerase chain reaction (PCR) testing can detect the DNA of the Lyme disease bacteria and if you have an active case of Lyme disease or if you had Lyme in the past. Use of IgM testing is recommended during the first 30 days of infection, after which only IgG tests should be used. Research shows that current western blot testing has shortcomings, and PCR testing is more valid in determining an active infection.
Supporting Lyme disease
Lyme disease is a serious illness that can have a significant impact on a person’s life. While there is no cure for Lyme disease, there are treatments available that can help manage the symptoms and improve quality of life. By seeking out natural treatments and support, Lyme disease sufferers can take an active role in managing their illness and improving their wellbeing.
If you think you may have Lyme disease, it is important to see your practitioner as soon as possible. Call Dr. Autoimmune 303-882-8447 or click the “Start Your Journey” button at the bottom of this page to find out more about how we can help.
Green tea has been used for centuries in Asia for its medicinal properties, and recent research has taught us that it may be an important tool for tackling autoimmunity. The extract from green tea has been shown to support T-regulatory cells, which help to suppress an overactive immune response and reduce inflammation. Sunphenon®, a decaffeinated and highly potent green tea extract, is a key ingredient in our proprietary supplement ImmunoXym that provides these benefits.
The Benefits
Green tea has been shown to have a number of health benefits thanks to its high polyphenol content. Polyphenols are antioxidants that help protect against oxidative stress and inflammation. Learn more about antioxidants, how they work, and another potent antioxidant in ImmunoXym here.
Green tea is also thermogenic, meaning it helps to boost metabolism and promote weight loss. In addition to all of this, green tea has been shown to protect against kidney damage, reduce risk of cancer, and control blood sugar levels. Simply put, green tea is a powerful tool for maintaining good health.
The Tea for T-Cells
According to research from Oregon State University, one of the beneficial compounds found in green tea has a powerful ability to increase the number of “regulatory T cells” that play a key role in immune function and suppression of autoimmune disease. Regulatory T cells (or “T-reg cells“) are a type of white blood cell that helps to keep the immune system in check, preventing it from overreacting and attacking healthy tissues. That’s why they are often referred to as the “police” of our immune system.
The major compound in green tea that they studied is a polyphenol called EGCG. In a study with mice, EGCG significantly increased the levels and activity of T-reg cells. The research was focused on potential treatments for lupus, but the findings have much broader implications for other autoimmune diseases such as multiple sclerosis, type 1 diabetes and rheumatoid arthritis. As stated by Mitzi Nagarkatti, an OSU professor and vice president for research:
“This is one of the most potent ways we’ve seen to increase the numbers and function of T-reg cells. These results are very exciting and could have broad implications for treatment of autoimmune disease.”
Medical College of Georgia researchers also say that green tea may help protect against autoimmune disease. Researchers studied an animal model for type 1 diabetes and Sjogren’s syndrome, which is an autoimmune condition that damages the glands that produce tears and saliva. The study found that green tea helped to reduce the production of inflammatory cytokines, which are molecules that play a role in the development of autoimmune disease by causing inflammation.
The Caffeine Drawback
Clearly green tea has a lot of benefits, but it also contains caffeine. Caffeine interferes with cortisol levels– the “stress hormone.” Cortisol is a hormone that helps us to deal with stress. When our cortisol levels are too high, we can feel anxious and stressed out. Caffeine can interfere with the normal production of cortisol, which can lead to feeling more stressed. It can also cause other problems such as insomnia, headaches, and gastrointestinal upset.
Sunphenon® is a decaffeinated, highly potent green tea extract that is used in our proprietary supplement for autoimmune patients, ImmunoXym. Sunphenon® is a powerful antioxidant that helps to protect cells from damage, and it has been shown to be effective in reducing the symptoms of autoimmune diseases by promoting T-reg cells.
ImmunoXym is a unique formula that is designed to support the body’s natural ability to stimulate these critical T-reg cells. Our supplement contains a blend of ingredients that are known to be effective in supporting immunity, and Sunphenon® is an important part of our formula. For the month of June, ImmunoXym will be 15% off in-office and 10% off online using code IAN10.
If you are ready to get to the root cause of your health issues and begin your healing journey, click the “Start Your Journey” button at the bottom of this page.
Hypertension, or high blood pressure, is the most common chronic disease in America. People with hypertension are at risk for heart attack, stroke, and kidney damage. Did you know that there is a connection between hypertension and autoimmune disease? Were you aware there are over 400 different causal factors in hypertension?
Autoimmunity is when your immune system attacks healthy cells in your body by mistake. The immune system is supposed to protect the body from infection and disease, but sometimes it breaks down and targets our own tissues.
Studies have shown that people with autoimmune diseases are more likely to develop hypertension, and vice versa. One study found that people with the autoimmune disease systemic lupus erythematosus (SLE), the most common type of lupus, were twice as likely to have hypertension than the general population. In fact, hypertension may even be autoimmune in itself. In this blog post, we will discuss the link between these two conditions and how our functional medicine approach can address them.
T Cells
T cells are a type of immune cell that helps the body fight infection. There are different types of T cells, including helper T cells and killer T cells. Helper T cells give instructions to other immune cells, and killer T cells kill infected or cancerous cells. Some T cells, called regulatory T cells or T-reg cells, help to keep the immune system in check. They are known as the “police” of the immune system.
Autoimmunity occurs when T-reg cells don’t work properly and other T cells become dysregulated. This can happen because of genetics, infections, exposure to certain chemicals or drugs, or hypertension. As a result, the immune system starts attacking healthy cells instead of fighting off infection. Autoimmunity can lead to a number of different diseases, including rheumatoid arthritis (RA), lupus, and multiple sclerosis (MS).
T Cells and Hypertension
T cells are a normal part of the immune system, but they can cause serious problems if they become overactive, as they do in autoimmune disease. T cells can cause high blood pressure, or hypertension. Hypertension is when the force of blood against the walls of blood vessels is too high. There is a bit of a vicious cycle because when hypertension damages the blood vessels, T cells are attracted to the area and cause inflammation. This can lead to further damage and make hypertension worse.
Oxidative stress, which can be caused by T cells, is another factor that can contribute to hypertension. This happens when there are too many free radicals in the body. Free radicals are molecules that can damage cells, and they are naturally created by T cells but can be worsened by things like smoking, pollution, and UV radiation from the sun. When oxidative stress happens, it can damage the arteries and make hypertension worse. Read more about how dysregulated T cells cause oxidative stress here.
Hypertension Leads to Autoimmunity
For many years, hypertension was thought to be caused by lifestyle choices or genetics. However, recent research about how dysregulated T cells lead to high blood pressure has shown that in some cases, hypertension may be an autoimmune disease in which the body’s immune system mistakenly attacks healthy blood vessels.
Essentially, since hypertension can lead to immune dysfunction, it can also lead to autoimmunity.
This research is still in its early stages, but it is hope for a better understanding of how to manage hypertension. This new information could lead to treatments that are more effective and have fewer side effects, as current blood pressure medications can lead to a variety of complications.
Other Triggers for Hypertension
DNA and Caffeine
Our risks for hypertension can be evaluated by looking at our DNA. An SNP (single nucleotide polymorphism) is a variation in a single nucleotide – the building blocks of DNA – that occurs at a specific position in the genome. SNP information can be used to understand how different people respond to caffeine, a substance that can increase blood pressure and cause hypertension.
For example, people with certain SNP variants may metabolize caffeine more slowly, which could lead to higher levels of caffeine in the blood and increased risk of hypertension. On the other hand, people with other SNP variants may metabolize caffeine more quickly, which could lead to lower levels of caffeine in the blood and reduced risk of hypertension. Therefore, SNP information can be used to understand how different people respond to caffeine and help to predict risks for certain health conditions.
Sleep Apnea
Sleep apnea is a serious medical condition that can lead to high blood pressure. When you have sleep apnea, your breathing stops and starts repeatedly during the night. This means that your body isn’t getting enough oxygen, which can put strain on your heart and other organs. Over time, this can lead to high blood pressure.
The Functional Medicine Approach
Autoimmune diseases are caused by a combination of genetics, leaky gut, and environmental triggers. While there is no cure for these conditions, research has shown that functional medicine can be an effective way to manage them. Functional medicine is a holistic approach that focuses on identifying and treating the root cause of disease. This approach involves using natural methods, such as diet, supplementation, and lifestyle changes to promote healing.
At Dr. Autoimmune, we focus on addressing the root cause of your condition and developing a custom plan with you to help you reach your health goals. If you are ready to be brave and take the Dr. Autoimmune challenge, click the “Start Your Journey” button at the bottom of this page.
“The best wealth is health,” said the Roman poet Virgil. You may also have heard, “You can have all of the money in the world, but if you don’t have your health, you have nothing.”
Our most recent health crisis has surely made these quotes true. Mental Health of America has shared some alarming statistics that include:
Nearly 50M or 19.68 % of American adults experienced mental illness in 2019.
4.58% of adults report having serious thoughts of suicide. This has increased every year since 2011-2021.
10.6% or over 2.5 million youth in the U.S. have severe major depression.
11.1% of Americans with a mental health issue are uninsured.
8.1% of children had private health insurance that did not cover mental health services totaling almost 1 million children.
What are Anxiety and Depression?
They are two different conditions, but they commonly occur together. Having the blues occasionally is normal, and everyone experiences anxious feelings at times. These are a common response to a stressful situation. It’s when those feelings become severe or ongoing that you may want to get to the root cause of the trigger. If you or a loved one shows early signs of depression, seek out a practitioner who can help.
1 in 4 people are affected by mental health illness at some point in their life. What and why are these staggering numbers increasing each year?
Research suggests that the microbiome (a community of microorganisms including viruses and bacteria) in your intestines may be related to brain functioning. By this definition, if your gut bugs are out of balance, and/or your intestinal lining permeability is enough to “leak” toxins into your bloodstream—guess where that gunk goes? It travels via your veins, your organs, and straight to your brain. Think of an ice cream headache. News travels fast!
How are the Gut and Brain Connected?
Sometimes referred to as your second brain, the gut communicates with your brain both physically and chemically.
The graphic below shows how your gut health can affect your mental health, or visa versa.
Antibiotics ~Not~ to the Rescue
What happens when you have an infection of any kind and you go to your general practitioner? You have an ear infection from too many summer hours spent in the pool, you get chronic sinus or respiratory infections, strep throat, urinary tract infections, acne, and the list goes on. What do all of these infections have in common besides a weakened immune response? They all are prescribed a 10-day round of antibiotics. Exposure to broad-spectrum antibiotics prescribed for the treatment of infectious diseases is one of the most common environmental factors which can affect the microbiome (Mayer et al., 2014).
It’s public knowledge that antibiotic resistance is a real thing. Compounded years of taking these flora destroying medications, along with other environmental factors can contribute to the leaky holes in our gut. In fact, more than 2.8 million antibiotic-resistant infections occur in the US each year.
A study including 5,244 subjects, none with diagnosed or reported anxiety or depression suggests that particularly male children who received antibiotic treatment for an infectious disease, may be at increased risk for future anxiety or depression. The mechanisms behind this outcome due to the disruption of the microbial balance in the gut. More research is needed to determine which, if not both the chicken (the infection) or the egg (the antibiotics) came in first place as the trigger for anxiety and depression.
Inflammation and Depression
70% of our immune system is located in the gut. Maintaining the proper balance of diversity is important so we can fight off infections, possible chronic disease, and psychosocial stressors. Research shows us that those residing in urban areas exposure to inflammatory responses are greater than those who are hunter-gatherers (think Paleo) or have a diverse agricultural-based lifestyle. “You are what you eat” has never been truer.
Go with Your Gut
Probiotics are live bacteria that are similar to the ones that are already in our gut. You can find them in fermented foods like yogurt, sauerkraut, and kimchi. They’re also in supplements. Along with testing, probiotic treatments may provide potential support and preventative measures for depressive and anxiety disorders. Researchers think that probiotics might work by affecting the way the brain and the gut communicate. Not all pre and probiotics are made equal. Talk with Dr. Ian or your practitioner to see which one may be right for you.
If you suffer with anxiety or depression and have a history of antibiotic use, give us a call to schedule a new patient exam at Dr. Autoimmune. We now have remote care options, so wherever you are, you can still receive great care and achieve results.
What Are Antioxidants?
“Antioxidant” is probably a term you have heard before. It is used commonly to refer to health beverage ingredients, so-called ‘superfoods’, and supplements as an anti-aging tool. But what is an antioxidant?
To understand how antioxidants work, you will need to understand what “free radicals” are. Free radicals are unstable atoms that are naturally made in the body. They are unstable because they do not have enough electrons, so they want to steal electrons from other atoms. When they steal electrons from our body’s atoms, it causes “oxidative stress” on our cells.
Oxidative stress, or free radicals stealing electrons from our bodies’ atoms, has been linked to a number of diseases such as:
In addition to all of these conditions, oxidative stress from free radicals also causes the effects of aging such as wrinkles, gray hair, vision decline, and hair loss. As we get older, our bodies produce more free radicals and have a harder time fighting them.
Now that you understand how free radicals cause oxidative stress, you will understand how antioxidants work. Free radicals need to steal electrons in order to become stable and stop causing damage. Antioxidants are special atoms that can donate their own electrons to the free radicals. Check out the image below to see how this works:
Some common antioxidants include vitamin C, vitamin E, beta-carotene, N-acetylcysteine (NAC), and our focus for this article: alpha lipoic acid (ALA).
How Antioxidants Help Autoimmunity
Oxidative stress from free radicals has been known to lead to autoimmunity because it messes with the immune system and causes inflammation. Here’s how:
Immune cells use free radicals to destroy bacteria, but when they start to produce too many, T-regulatory cells use them to suppress the immune cells. This is one way that T-reg cells ‘police’ the immune system. When immune cells are dysregulated (T-reg cells aren’t working right), they produce more free radicals, which increases inflammation. This is how oxidative stress dysregulates the immune system.
In fact, one study found that oxidative stress was a huge contributor to damage done by the autoimmune disease systemic lupus erythematosus (SLE), the most common type of lupus. Free radicals increased inflammation, organ damage, and the chance of developing a second disease.
Since we know that oxidative stress can cause autoimmunity, it makes sense that antioxidants may help with managing autoimmune diseases. Studies have actually shown that this theory is true.
ALA and Autoimmunity
Alpha lipoic acid (ALA) is an antioxidant that our cells make naturally. We can also supplement with it and get great results, as some scientists have already tested.
Multiple sclerosis (MS) is an autoimmune disease that affects your body’s nervous system. The version of this disease that mice can get is called EAE. When mice with this disease were given high doses of ALA early on, the disease was completely suppressed. The ALA helped regulate the immune system in the mice and was able to completely stop it from attacking their central nervous systems. The implications for humans with MS are very exciting. Even in mice that already had very serious symptoms, the ALA slowed down their disease progression and reduced their symptoms.
Our very own Dr. Ian Hollaman (a.k.a Dr. Autoimmune) developed a supplement formula for his autoimmune patients. Immunoxym is specifically made to support your T-regulatory cells, which are the ‘police’ of your immune system. One of the most important ingredients is ALA.
For the month of June, you can purchase Immunoxym for 10% off online using code IAN10 at checkout, and 15% off if you purchase in the office.
With an 85% success rate for resolution of symptoms, we are confident that we can get to the root cause of your condition and develop a custom plan with you that will help you reach your health goals. If you are ready to be brave and take the Dr. Autoimmune challenge, click “Start Your Journey” at the bottom of this page!
Your habits influence your attitude, sleep, food cravings…and autoimmunity. Many of you that suspect you may have an autoimmune condition, or have been diagnosed with one, may in fact have two or more lurking within.
Have you noticed that when you eat pleasure-seeking foods such as sweets, alcohol, or caffeine (and for some, Chinese food), you want more of it shortly after you consume them? In an age of sugar-free, Keto, and every diet under the sun, where does real sugar stop and artificial sweeteners start?
Every restaurant table and coffee bar have these colorful, single-serving sized packets screaming at your taste buds, “Hey Sweet Tooth, I’m down here.” A laboratory accident turned popular over 130 years ago and the first super villain, saccharin, made its way into our food chain as a cheap and calorie-free alternative to cane sugar. Originally it was believed to be harmless, but over time, its question of safety rode a rollercoaster between science and industrial priorities.
Celebrities in the the cooking world have nothing good to say about these fake sweeteners. Colleague, close friend, and cookbook editor to Julia Child, Avis DeVoto wrote:
“Desserts, of which there is a fat section, are incredible—sweetened with saccharin [sic] and topped with imitation whipped cream! Fantastic! And I do believe a lot of people in this country eat just like that, stuffing themselves with faked materials in the fond belief that by substituting a chemical for God’s good food they can keep themselves slim while still eating hot breads and desserts and GUNK.”
To say the least, she was not a fan of this fake food and considered saccharin an empty pleasure.
When sugar became scarce during World War II, this diabetic substitute’s production ramped up. Between 1963 and 1967 artificially sweetened soft drinks nearly tripled their market share. By 1979, 44 million Americans used this sickly sweet, zero calorie alternative daily. As you can see by this chart, the rise has not slowed down, and is contributing to the obesity epidemic in America.
Chemical named by brand:
Acesulfame Potassium – Sunnett, Sweet One
Aspartame – Nutrasweet, Equal
Neotame – N/A
Saccharin – Sweet ‘N Low, Sweet Twin, Sugar Twin.
Sucralose – Splenda
Nutrition is among one of the contributing leaders to leaky gut syndrome. When foods are laden with pesticides, chemicals, artificial sweeteners and colors, combined with our nutrient deficient foods, our gut is constantly under attack and is no match for these “gut busting” toxins. If our food sources can not naturally support and feed the good bacteria, the bad bacteria begin to take over. Along with a nutrient dense diet, pharmaceutical grade supplementation has become paramount in therapeutic doses in order to restore our gut balance to tackle our autoimmune risk and conditions.
The sweet taste receptor (T1R3) is activated by artificial sweeteners. At high concentrations, many of the aforementioned chemical compounds were found to increase leaky gut and degrade cell regulation. This can lead to a myriad of issues including insulin resistance and diabetes. Primarily and first most, leaky gut leads to inflammation>symptoms>autoimmunity.
What about the reportedly safe “new age” sweeteners?
Chicory
Coconut sugar
Honey
Maple Syrup
Monk Fruit
Stevia
Although a monumental improvement in the form of nature vs lab, sugar in any form can spike your blood sugar and cause imbalances if consumed frequently (have you heard about devices which monitor your blood sugar?).
Grandma always said, “everything in moderation”. Unlike natural sugars including honey, maple syrup, and coconut sugar, stevia may be the lead in this cast of best choices for a sweet alternative, touting that it remains neutral in your bloodstream, and has a reduced calorie intake and low risk of cavities.
It has been reported that stevia could interfere with good bacteria in the gut, a strain on your kidneys or other organs, and/or possibly lower blood pressure, which could interfere with those on high blood pressure medications. There are always two sides to every story, and there isn’t enough research to conclude its downfalls. Just another reason to see an integrative or functional practitioner to get to the root cause of your tummy troubles.
The bottom line is: eat as close to the farm and whole food as possible. Teach your children at a young age how to read an ingredient label at the grocery store. It’s a fun and educational game that supports awareness around what is actually food, and what are lab experiments. Remember, you are what you eat. Bon Appetit!
It may be hard to believe, but brushing your teeth can help your joints. All dentists will tell you that your dental health is tied to your physical health, but how seriously do we really take that? Your mouth has its own microbiome, which is the mini ecosystem made up of bacteria and other small life forms, just like your gut and your skin. When any of your microbiomes are out of balance, there will be consequences.
Rheumatoid arthritis (RA) is an autoimmune disease, which is a type of disease where someone’s body attacks itself. In the case of RA, the body is attacking the joints, causing painful inflammation that limits range of motion and affects daily activities. Many people with RA find themselves unable to run, walk, lift things, or even use their hands without severe pain.
How Does RA Start?
In functional medicine, our goal is to discover the root cause of disease. What we’ve learned is that all autoimmune diseases require three things in order to develop:
Genes: Without the genes for an autoimmune condition, the disease cannot manifest. Genes are not a life sentence, though. We have some control over whether our genes are actually expressed or “stay asleep”. Just because you have the genes, doesn’t mean you’ll have the condition!
Leaky gut: The cells that make up our intestine lining are held together by tight junctions, which are important for keeping our partially-digested food from seeping out. Many factors, including gluten and NSAIDs such as Ibuprofen, cause these tight junctions to loosen and allow material to leak out, which causes inflammation in the body. Read more about the gut’s connection to RA here.
Last but not least, a trigger: Many things can trigger an autoimmune response, including viral or bacterial infections.
One specific type of bacterial infection has been tied to RA as a trigger. The bacteria is called Porphyromonas gingivalis and is also a common culprit behind periodontal disease, a common gum disease. In periodontal disease, an infection causes inflammation in the gums and can lead to symptoms such as:
Swollen, red, and tender gums
Bleeding gums
In more serious cases, tooth loss (periodontitis)
Gum Disease and RA
Have you ever wondered what plaque on your teeth actually is? Bacteria such as P. gingivalis produce a sticky film that can build up- and that becomes plaque! The bacteria in plaque create acids, which slowly break down tooth enamel. Not only does the yellowish film not look pretty, but it can lead to gum disease andrheumatoid arthritis. P. gingivalis causes nasty inflammation in the gums, as you can see in the picture above, so just imagine the inflammation it can cause in your joints!
It has become clear that periodontal disease and periodontitis are linked to RA, but recent research has been able to narrow down the link to P. gingivalis bacteria specifically.
In this study, mice that were infected with P. gingivalis bacteria either developed arthritis, or their already existing arthritis got worse. Another study found that the correlation between the antibody to P. gingivalis and RA was even stronger- in fact, two times stronger- than the correlation between smoking and RA. Smoking has been a known major risk factor for RA for many years, but now we know that periodontal disease caused by P. gingivalis bacteria is more than twice as likely to lead to RA. Do you believe the dentists now?
Your RA Might Have a “Friend”
For the most part, good dental hygiene can keep bad bacteria from running rampant. Brushing and flossing twice a day as well as regular visits to a dentist are important steps to take. One way that P. gingivalis can grow is if your mouth is too dry. Unfortunately, another autoimmune condition, Sjögren’s syndrome, specifically attacks the salivary glands and leaves the mouth very dry. Sjögren’s is therefore a risk factor for plaque buildup and periodontal disease. Given what we just learned about the connection between periodontal disease and RA, it should be no surprise that 21% of Sjögren’s patients have also been diagnosed with rheumatoid arthritis.
This is a common theme in our office: Many people who have been diagnosed with one autoimmune disease also develop another one or more. In fact, at the time someone is diagnosed with an autoimmune disease, there is a 50% chance that another one already exists. If the genes are there and the environment allows one disease to develop, then it is very likely that other autoimmune genes will be triggered.
At Dr. Autoimmune, we use a functional medicine approach to get to the root cause of complex conditions. Our structured program removes the guesswork and uses science-backed lab testing, diet change, and supplementation to get your body back on track. Using this method, we have an 85% success rate. If you’re interested in finding real solutions for your conditions, fill out the form below to get started!
95% of the good microbes in your body are in your gut. When in balance, these tiny organisms work together with your body to support many important systems, such as your immune system. In fact, 70-80% of your immune cells are in your gut! The tiny ecosystem of microbes in your stomach and intestines is known as your “gut microbiome”.
A problem occurs when the good microbes are overpowered by bad microbes. This creates a state of imbalance known as “gut dysbiosis”. Since your gut microbiome is so essential to the proper functioning of many of your body’s systems, gut dysbiosis is linked to various diseases- even brain diseases- such as:
Type 2 diabetes
Inflammatory bowel disease
Alzheimer’s disease
Parkinson’s disease
Amyotrophic lateral sclerosis
What affects your gut microbiota? Stress, alcohol, certain foods, the use of antibiotics can all harm the good microbes in your gut, leading to gut dysbiosis. Gut dysbiosis can also cause inflammation, which can lead to what we call “leaky gut”.
The lining of your intestines is important for keeping most material inside your gut, while also letting things like water and nutrients be absorbed through it. In order to let certain things through the barrier, your intestine lining has to be somewhat permeable by having gaps between cells. However, when the gaps become too big due to inflammation, bigger particles can seep through. This is how leaky gut starts.
Food particles that escape your intestinal lining cause more inflammation. This is why leaky gut can is linked to inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
The backbone of our immune system lies in our gut. When we have gut dysbiosis, leaky gut, and inflammation, our immune system can become dysregulated. This leads to a loss of tolerance for certain foods, environmental substances such as chemicals, and eventually our own cells.
3 Red Flags for Leaky Gut
Food sensitivities
Environmental sensitivities
Autoimmune disease
Healing Leaky Gut With Functional Medicine
As a functional medicine office, our focus is to dig deeper and address chronic health concerns by getting to the root cause. Because leaky gut is often the root cause of most inflammatory disorders and autoimmune diseases, our care is very gut-focused.
One of the most common questions asked in the natural health community is, “How do I fix my gut?” The problem is that this is not exactly a one-size-fits-all situation! Our personalized plans are designed to find and remove your specific triggers, which are not the same for everyone.
Probiotics
Since gut dysbiosis is a factor contributing to leaky gut, it is beneficial to add healthy bacteria back into the gut to “take up parking spots” and out-compete bad bacteria. Dr. Ian Hollaman uses advanced GI testing to identify exactly which strains of probiotics will be most beneficial for each patient.
Sometimes, before adding in good bacteria, the gut needs to be cleared of an infection, or overgrowth, of bad bacteria. Small intestine bacterial overgrowth (SIBO) is a difficult monster to tackle, but we have successfully helped many of our patients get it under control.
Prebiotics
Eating a fiber-rich diet gives the good bacteria in your gut plenty of good food! This is another way to help their populations grow.
Polyphenols
Polyphenols are antioxidants that help reduce stress on your body’s cells, therefore reducing inflammation. A recent study found that eating a polyphenol-rich diet for 8 weeks helped change the gut microbiota and therefore reduced intestinal permeability (aka leaky gut). This study used polyphenols from cocoa and green tea.
Dr. Ian’s proprietary supplement ImmunoXym contains caffeine-free green tea extract for its polyphenol content along with a specially formulated blend of probiotics and a slew of other vitamins essential for your immune system to regulate itself.
Glutamine
Glutamine supplementation has been shown to dramatically and safely reduce symptoms in IBS patients that have leaky gut.
The Dr. Autoimmune Difference
At Dr. Autoimmune, we use a functional medicine approach to address the root cause of leaky gut and all other gut issues. Our solutions are always natural, always personalized, and always backed by science. If you are ready to change your life, click the “Start Your Journey” button at the bottom of this page!
Juvenile idiopathic arthritis (JIA), formerly known as juvenile rheumatoid arthritis (RA), is joint inflammation in children 16 years of age or younger, lasting for at least 6 weeks. Unlike adult rheumatoid arthritis (RA) that is chronic and can last a lifetime without proper diagnosis or intervention, children usually outgrow JIA. But do they really?
JIA is…drum roll please…an autoimmune disease. Children with predisposed genes, such as a part of a gene called HLA antigen DR4, could be at a higher risk for developing JIA. Even if the symptoms of JIA subside, the risk of developing an autoimmune condition later in life is probable. All autoimmune conditions can be connected to “leaky gut”, a problem where the gut barrier breaks down and inflammation begins to trigger an autoimmune response. Even if your child does not have gut-related symptoms, it is quite common that those with JIA have small intestinal bacterial overgrowth, undergrowth, or other infectious bugs that must be brought under control with proper evaluation and support.
There is evidence that early exposure to antibiotics and compromised gut health could be contributing factors. Additional studies support the connection between JIA, type 1 diabetes, food allergies, and inflammatory bowel disease (IBS). Infants who were born vaginally vs. by c-section tend to have more Bifidobacterium in their gut, which is associated with a strong immune response. Nursed infants also have higher levels of this same beneficial bacteria in addition to Lactobacilli and Streptococci. Bottle-fed infants could be lacking these healthy bacteria, and may be at increased risk of developing an autoimmune disease.
Systemic onset JIA affects one or more joints, combined with high fever and a skin rash. It may also cause inflammation of internal organs, including the heart, liver, spleen, and lymph nodes. It is the least common type. It affects 1 in 10 to about 1 in 7 children with JIA.
Oligoarticular JIA affects 1 to 4 joints in the first 6 months of disease. If no more joints are affected after 6 months, this type is called persistent. If more joints are affected after 6 months, it is called extended.
Polyarticular JIA affects 5 or more joints in the first 6 months of disease. Blood tests for rheumatoid factor (RF) will show if this type is RF-positive or RF-negative.
Enthesitis-related JIA is arthritis and swelling of the tissue where bone meets a tendon or ligament. It often affects the hips, knees, and feet.
Psoriatic arthritis may have both arthritis and a red, scaly skin disease called psoriasis. 2 or more of the following symptoms may be present:
Inflammation of a finger or toe
Pits or ridges in fingernails
A first-degree relative with psoriasis
Undifferentiated arthritis is arthritis that has symptoms of 2 or more JIA types above. Or the symptoms might not match any type of JIA.
How do you know if your child may have JIA? A physical exam may not be enough to determine a clear diagnosis. A MRI or X-ray could show the degree of inflammation, and a comprehensive blood panel may show the presence of the substance’s antinuclear antibody (ANA) and rheumatoid factor. These tests can help rule out other diseases. As well, the most significant and accurate marker for rheumatoid arthritis, cyclic citrullinated peptides (CCP) should be run.
Functional medicine excels at this aspect of determining the root cause and how to rehab the immune system. If you suspect your child may have juvenile idiopathic arthritis, Dr. Autoimmune can help. Click the “Start Your Journey” button at the bottom of this page or call today to schedule a new patient evaluation with Dr. Ian Hollaman: 303-882-8447, press 0 to speak with Felice.
Eating healthy isn’t always enough. We can eat a variety of organic vegetables, fruits, and meats and still be missing out on the macronutrients that these foods deliver. Poor soil health from overcropping leads to less nutrient-dense foods, and our internal gut health may be missing the “good stuff” that helps us absorb and digest these “healthy” food sources.
Your digestive juices include hydrochloric acid (HCL), several enzymes, and a mucus coating that protects the lining of your stomach. Hydrochloric acid helps your body to break down, digest, and absorb nutrients such as protein. It also eliminates bacteria and viruses in the stomach, protecting your body from infection.
Hypochlorhydria is the state of having low stomach acid. This condition can be caused by consuming poor quality, highly processed foods, alcohol or smoking. Normal aging can also be a contributor to decreased hydrochloric acid. For those with hypochlorhydria, supplementing may be the answer to finding the balance for your metabolic system. Taking medications that suppress the symptoms of acid reflux (a symptom of hypochlorhydria) have been shown to contribute to leaky gut. Chronic gastrointestinal complaints are often addressed with medications that often make the bark worse than the bite.
How do you know if you are digesting and absorbing those organic foods that you so carefully cultivate or purchase?
If you have many of the symptoms above, and suspect you may not be utilizing your nutrients effectively, try taking the HCL Challenge described in this link. The basic concept is to take one HCL pill with each meal on day one, 2 with each meal on day 2, 3 with each meal on day 3 and so on. When you reach heartburn within 5 minutes after taking the dose, that will be the point where you want to back off by one pill each meal until you can dismiss the heartburn. Remember that we are all bio-individual and may react differently, so please consult your practitioner if you have any questions or concerns.
HCL-XYM to the Rescue
HCL-XYM is a blend of betaine hydrochloride (HCL) and the three most effective plant-based digestive enzymes: protease, amylase and lipase, in a base of trace minerals. All Dr. Autoimmune clients take HCL-XYM prior to every meal in order to:
help support the body’s natural ability to produce HCL
offer relief from occasional gas, bloating and indigestion
support digestion and absorption
create the proper pH in which protein digestion enzymes work
help to extract vitamin B12 from food
maintain healthy intestinal flora levels
If you suffer from many of these symptoms, HCL-XYM could help support your digestion. Call Dr. Autoimmune to discuss options on how we can get to the root cause of your symptoms at 303-882-8447.
For the month of July, we will be offering HCL-XYM at 15% off retail in office purchases only. Or, you can order online here, enter one-time access code USE777, and use code IAN10 at checkout for 10% off.
See what Dr. Autoimmune suggests eating to support your gut and immune health here.
Learn about the link between ticks, Lyme disease and autoimmune disease and how to protect yourself from this dangerous trio.
These itty bitty bugs climb out as cold weather fades. Particularly in woody, adventure-seeking communities like Colorado, people take to the outdoors (and so do the ticks!).
Ticks are No Treat
Ticks are tiny insects that attach themselves to the skin of animals and humans. Lyme disease is a bacterial infection that is transmitted to humans through the bite of an infected tick. The symptoms of Lyme disease can vary, but they often include”:
Fever
Headache
Fatigue
A distinctive rash known as erythema migrans
If Lyme disease is not treated, it can spread to the joints, heart, and nervous system. In some cases, Lyme disease can lead to an autoimmune condition. Autoimmunity occurs when the body’s immune system mistakenly attacks healthy tissues. This can occur in people with Lyme disease if the bacteria spreads to the liver and triggers an autoimmune response. In severe cases, autoimmunity can cause organ damage and even death. Lyme disease is a serious condition that requires prompt treatment. Ticks can also carry other diseases, including Rocky Mountain spotted fever and babesiosis (Lyme co-infection), but Lyme disease is the most common tick-borne infection in North America.
There are more than 80 different types of autoimmune diseases, and they affect people of all ages. Lyme disease is a serious health problem and can lead to autoimmunity, but there are steps you can take to protect yourself from ticks and other insects that carry the disease. You should wear long pants and sleeves when you are outdoors in areas where ticks live. You should also use natural insect repellent (made with essential oils) on your skin and clothing. Be sure to check yourself and your pets for ticks after spending time outdoors, and remove any that are found promptly.
It’s often very difficult to diagnose a Lyme infection. Many people live with undiagnosed symptoms for years before getting to the root cause. Lyme disease is best detected by a blood test, which looks for antibodies to the Lyme bacteria. The test can be performed using either a whole blood sample or a serum sample. Antibodies to Lyme disease are typically produced within 3-6 weeks of infection, so it is best to wait at least 6 weeks after possible exposure before getting tested. It’s important to get proper testing as not all tests are created equal. Lyme disease can also be detected using a urine test, but this is not as accurate as the blood test. Lyme disease is a serious infection that can cause a wide range of symptoms, so it is important to get tested if you think you may have been exposed to the bacteria.
All Testing is Not Created Equal
It is important to use the proper type of testing for Lyme. Polymerase chain reaction (PCR) testing can detect the DNA of the Lyme disease bacteria and if you have an active case of Lyme disease or if you had Lyme in the past. Use of IgM testing is recommended during the first 30 days of infection, after which only IgG tests should be used. Research shows that current western blot testing has shortcomings, and PCR testing is more valid in determining an active infection.
Supporting Lyme disease
Lyme disease is a serious illness that can have a significant impact on a person’s life. While there is no cure for Lyme disease, there are treatments available that can help manage the symptoms and improve quality of life. By seeking out natural treatments and support, Lyme disease sufferers can take an active role in managing their illness and improving their wellbeing.
If you think you may have Lyme disease, it is important to see your practitioner as soon as possible. Call Dr. Autoimmune 303-882-8447 or click the “Start Your Journey” button at the bottom of this page to find out more about how we can help.
Green tea has been used for centuries in Asia for its medicinal properties, and recent research has taught us that it may be an important tool for tackling autoimmunity. The extract from green tea has been shown to support T-regulatory cells, which help to suppress an overactive immune response and reduce inflammation. Sunphenon®, a decaffeinated and highly potent green tea extract, is a key ingredient in our proprietary supplement ImmunoXym that provides these benefits.
The Benefits
Green tea has been shown to have a number of health benefits thanks to its high polyphenol content. Polyphenols are antioxidants that help protect against oxidative stress and inflammation. Learn more about antioxidants, how they work, and another potent antioxidant in ImmunoXym here.
Green tea is also thermogenic, meaning it helps to boost metabolism and promote weight loss. In addition to all of this, green tea has been shown to protect against kidney damage, reduce risk of cancer, and control blood sugar levels. Simply put, green tea is a powerful tool for maintaining good health.
The Tea for T-Cells
According to research from Oregon State University, one of the beneficial compounds found in green tea has a powerful ability to increase the number of “regulatory T cells” that play a key role in immune function and suppression of autoimmune disease. Regulatory T cells (or “T-reg cells“) are a type of white blood cell that helps to keep the immune system in check, preventing it from overreacting and attacking healthy tissues. That’s why they are often referred to as the “police” of our immune system.
The major compound in green tea that they studied is a polyphenol called EGCG. In a study with mice, EGCG significantly increased the levels and activity of T-reg cells. The research was focused on potential treatments for lupus, but the findings have much broader implications for other autoimmune diseases such as multiple sclerosis, type 1 diabetes and rheumatoid arthritis. As stated by Mitzi Nagarkatti, an OSU professor and vice president for research:
“This is one of the most potent ways we’ve seen to increase the numbers and function of T-reg cells. These results are very exciting and could have broad implications for treatment of autoimmune disease.”
Medical College of Georgia researchers also say that green tea may help protect against autoimmune disease. Researchers studied an animal model for type 1 diabetes and Sjogren’s syndrome, which is an autoimmune condition that damages the glands that produce tears and saliva. The study found that green tea helped to reduce the production of inflammatory cytokines, which are molecules that play a role in the development of autoimmune disease by causing inflammation.
The Caffeine Drawback
Clearly green tea has a lot of benefits, but it also contains caffeine. Caffeine interferes with cortisol levels– the “stress hormone.” Cortisol is a hormone that helps us to deal with stress. When our cortisol levels are too high, we can feel anxious and stressed out. Caffeine can interfere with the normal production of cortisol, which can lead to feeling more stressed. It can also cause other problems such as insomnia, headaches, and gastrointestinal upset.
Sunphenon® is a decaffeinated, highly potent green tea extract that is used in our proprietary supplement for autoimmune patients, ImmunoXym. Sunphenon® is a powerful antioxidant that helps to protect cells from damage, and it has been shown to be effective in reducing the symptoms of autoimmune diseases by promoting T-reg cells.
ImmunoXym is a unique formula that is designed to support the body’s natural ability to stimulate these critical T-reg cells. Our supplement contains a blend of ingredients that are known to be effective in supporting immunity, and Sunphenon® is an important part of our formula. For the month of June, ImmunoXym will be 15% off in-office and 10% off online using code IAN10.
If you are ready to get to the root cause of your health issues and begin your healing journey, click the “Start Your Journey” button at the bottom of this page.
Hypertension, or high blood pressure, is the most common chronic disease in America. People with hypertension are at risk for heart attack, stroke, and kidney damage. Did you know that there is a connection between hypertension and autoimmune disease? Were you aware there are over 400 different causal factors in hypertension?
Autoimmunity is when your immune system attacks healthy cells in your body by mistake. The immune system is supposed to protect the body from infection and disease, but sometimes it breaks down and targets our own tissues.
Studies have shown that people with autoimmune diseases are more likely to develop hypertension, and vice versa. One study found that people with the autoimmune disease systemic lupus erythematosus (SLE), the most common type of lupus, were twice as likely to have hypertension than the general population. In fact, hypertension may even be autoimmune in itself. In this blog post, we will discuss the link between these two conditions and how our functional medicine approach can address them.
T Cells
T cells are a type of immune cell that helps the body fight infection. There are different types of T cells, including helper T cells and killer T cells. Helper T cells give instructions to other immune cells, and killer T cells kill infected or cancerous cells. Some T cells, called regulatory T cells or T-reg cells, help to keep the immune system in check. They are known as the “police” of the immune system.
Autoimmunity occurs when T-reg cells don’t work properly and other T cells become dysregulated. This can happen because of genetics, infections, exposure to certain chemicals or drugs, or hypertension. As a result, the immune system starts attacking healthy cells instead of fighting off infection. Autoimmunity can lead to a number of different diseases, including rheumatoid arthritis (RA), lupus, and multiple sclerosis (MS).
T Cells and Hypertension
T cells are a normal part of the immune system, but they can cause serious problems if they become overactive, as they do in autoimmune disease. T cells can cause high blood pressure, or hypertension. Hypertension is when the force of blood against the walls of blood vessels is too high. There is a bit of a vicious cycle because when hypertension damages the blood vessels, T cells are attracted to the area and cause inflammation. This can lead to further damage and make hypertension worse.
Oxidative stress, which can be caused by T cells, is another factor that can contribute to hypertension. This happens when there are too many free radicals in the body. Free radicals are molecules that can damage cells, and they are naturally created by T cells but can be worsened by things like smoking, pollution, and UV radiation from the sun. When oxidative stress happens, it can damage the arteries and make hypertension worse. Read more about how dysregulated T cells cause oxidative stress here.
Hypertension Leads to Autoimmunity
For many years, hypertension was thought to be caused by lifestyle choices or genetics. However, recent research about how dysregulated T cells lead to high blood pressure has shown that in some cases, hypertension may be an autoimmune disease in which the body’s immune system mistakenly attacks healthy blood vessels.
Essentially, since hypertension can lead to immune dysfunction, it can also lead to autoimmunity.
This research is still in its early stages, but it is hope for a better understanding of how to manage hypertension. This new information could lead to treatments that are more effective and have fewer side effects, as current blood pressure medications can lead to a variety of complications.
Other Triggers for Hypertension
DNA and Caffeine
Our risks for hypertension can be evaluated by looking at our DNA. An SNP (single nucleotide polymorphism) is a variation in a single nucleotide – the building blocks of DNA – that occurs at a specific position in the genome. SNP information can be used to understand how different people respond to caffeine, a substance that can increase blood pressure and cause hypertension.
For example, people with certain SNP variants may metabolize caffeine more slowly, which could lead to higher levels of caffeine in the blood and increased risk of hypertension. On the other hand, people with other SNP variants may metabolize caffeine more quickly, which could lead to lower levels of caffeine in the blood and reduced risk of hypertension. Therefore, SNP information can be used to understand how different people respond to caffeine and help to predict risks for certain health conditions.
Sleep Apnea
Sleep apnea is a serious medical condition that can lead to high blood pressure. When you have sleep apnea, your breathing stops and starts repeatedly during the night. This means that your body isn’t getting enough oxygen, which can put strain on your heart and other organs. Over time, this can lead to high blood pressure.
The Functional Medicine Approach
Autoimmune diseases are caused by a combination of genetics, leaky gut, and environmental triggers. While there is no cure for these conditions, research has shown that functional medicine can be an effective way to manage them. Functional medicine is a holistic approach that focuses on identifying and treating the root cause of disease. This approach involves using natural methods, such as diet, supplementation, and lifestyle changes to promote healing.
At Dr. Autoimmune, we focus on addressing the root cause of your condition and developing a custom plan with you to help you reach your health goals. If you are ready to be brave and take the Dr. Autoimmune challenge, click the “Start Your Journey” button at the bottom of this page.
“The best wealth is health,” said the Roman poet Virgil. You may also have heard, “You can have all of the money in the world, but if you don’t have your health, you have nothing.”
Our most recent health crisis has surely made these quotes true. Mental Health of America has shared some alarming statistics that include:
Nearly 50M or 19.68 % of American adults experienced mental illness in 2019.
4.58% of adults report having serious thoughts of suicide. This has increased every year since 2011-2021.
10.6% or over 2.5 million youth in the U.S. have severe major depression.
11.1% of Americans with a mental health issue are uninsured.
8.1% of children had private health insurance that did not cover mental health services totaling almost 1 million children.
What are Anxiety and Depression?
They are two different conditions, but they commonly occur together. Having the blues occasionally is normal, and everyone experiences anxious feelings at times. These are a common response to a stressful situation. It’s when those feelings become severe or ongoing that you may want to get to the root cause of the trigger. If you or a loved one shows early signs of depression, seek out a practitioner who can help.
1 in 4 people are affected by mental health illness at some point in their life. What and why are these staggering numbers increasing each year?
Research suggests that the microbiome (a community of microorganisms including viruses and bacteria) in your intestines may be related to brain functioning. By this definition, if your gut bugs are out of balance, and/or your intestinal lining permeability is enough to “leak” toxins into your bloodstream—guess where that gunk goes? It travels via your veins, your organs, and straight to your brain. Think of an ice cream headache. News travels fast!
How are the Gut and Brain Connected?
Sometimes referred to as your second brain, the gut communicates with your brain both physically and chemically.
The graphic below shows how your gut health can affect your mental health, or visa versa.
Antibiotics ~Not~ to the Rescue
What happens when you have an infection of any kind and you go to your general practitioner? You have an ear infection from too many summer hours spent in the pool, you get chronic sinus or respiratory infections, strep throat, urinary tract infections, acne, and the list goes on. What do all of these infections have in common besides a weakened immune response? They all are prescribed a 10-day round of antibiotics. Exposure to broad-spectrum antibiotics prescribed for the treatment of infectious diseases is one of the most common environmental factors which can affect the microbiome (Mayer et al., 2014).
It’s public knowledge that antibiotic resistance is a real thing. Compounded years of taking these flora destroying medications, along with other environmental factors can contribute to the leaky holes in our gut. In fact, more than 2.8 million antibiotic-resistant infections occur in the US each year.
A study including 5,244 subjects, none with diagnosed or reported anxiety or depression suggests that particularly male children who received antibiotic treatment for an infectious disease, may be at increased risk for future anxiety or depression. The mechanisms behind this outcome due to the disruption of the microbial balance in the gut. More research is needed to determine which, if not both the chicken (the infection) or the egg (the antibiotics) came in first place as the trigger for anxiety and depression.
Inflammation and Depression
70% of our immune system is located in the gut. Maintaining the proper balance of diversity is important so we can fight off infections, possible chronic disease, and psychosocial stressors. Research shows us that those residing in urban areas exposure to inflammatory responses are greater than those who are hunter-gatherers (think Paleo) or have a diverse agricultural-based lifestyle. “You are what you eat” has never been truer.
Go with Your Gut
Probiotics are live bacteria that are similar to the ones that are already in our gut. You can find them in fermented foods like yogurt, sauerkraut, and kimchi. They’re also in supplements. Along with testing, probiotic treatments may provide potential support and preventative measures for depressive and anxiety disorders. Researchers think that probiotics might work by affecting the way the brain and the gut communicate. Not all pre and probiotics are made equal. Talk with Dr. Ian or your practitioner to see which one may be right for you.
If you suffer with anxiety or depression and have a history of antibiotic use, give us a call to schedule a new patient exam at Dr. Autoimmune. We now have remote care options, so wherever you are, you can still receive great care and achieve results.
“Antioxidant” is probably a term you have heard before. It is used commonly to refer to health beverage ingredients, so-called ‘superfoods’, and supplements as an anti-aging tool. But what is an antioxidant?
To understand how antioxidants work, you will need to understand what “free radicals” are. Free radicals are unstable atoms that are naturally made in the body. They are unstable because they do not have enough electrons, so they want to steal electrons from other atoms. When they steal electrons from our body’s atoms, it causes “oxidative stress” on our cells.
Oxidative stress, or free radicals stealing electrons from our bodies’ atoms, has been linked to a number of diseases such as:
In addition to all of these conditions, oxidative stress from free radicals also causes the effects of aging such as wrinkles, gray hair, vision decline, and hair loss. As we get older, our bodies produce more free radicals and have a harder time fighting them.
Now that you understand how free radicals cause oxidative stress, you will understand how antioxidants work. Free radicals need to steal electrons in order to become stable and stop causing damage. Antioxidants are special atoms that can donate their own electrons to the free radicals. Check out the image below to see how this works:
Some common antioxidants include vitamin C, vitamin E, beta-carotene, N-acetylcysteine (NAC), and our focus for this article: alpha lipoic acid (ALA).
How Antioxidants Help Autoimmunity
Oxidative stress from free radicals has been known to lead to autoimmunity because it messes with the immune system and causes inflammation. Here’s how:
Immune cells use free radicals to destroy bacteria, but when they start to produce too many, T-regulatory cells use them to suppress the immune cells. This is one way that T-reg cells ‘police’ the immune system. When immune cells are dysregulated (T-reg cells aren’t working right), they produce more free radicals, which increases inflammation. This is how oxidative stress dysregulates the immune system.
In fact, one study found that oxidative stress was a huge contributor to damage done by the autoimmune disease systemic lupus erythematosus (SLE), the most common type of lupus. Free radicals increased inflammation, organ damage, and the chance of developing a second disease.
Since we know that oxidative stress can cause autoimmunity, it makes sense that antioxidants may help with managing autoimmune diseases. Studies have actually shown that this theory is true.
ALA and Autoimmunity
Alpha lipoic acid (ALA) is an antioxidant that our cells make naturally. We can also supplement with it and get great results, as some scientists have already tested.
Multiple sclerosis (MS) is an autoimmune disease that affects your body’s nervous system. The version of this disease that mice can get is called EAE. When mice with this disease were given high doses of ALA early on, the disease was completely suppressed. The ALA helped regulate the immune system in the mice and was able to completely stop it from attacking their central nervous systems. The implications for humans with MS are very exciting. Even in mice that already had very serious symptoms, the ALA slowed down their disease progression and reduced their symptoms.
Our very own Dr. Ian Hollaman (a.k.a Dr. Autoimmune) developed a supplement formula for his autoimmune patients. Immunoxym is specifically made to support your T-regulatory cells, which are the ‘police’ of your immune system. One of the most important ingredients is ALA.
For the month of June, you can purchase Immunoxym for 10% off online using code IAN10 at checkout, and 15% off if you purchase in the office.
With an 85% success rate for resolution of symptoms, we are confident that we can get to the root cause of your condition and develop a custom plan with you that will help you reach your health goals. If you are ready to be brave and take the Dr. Autoimmune challenge, click “Start Your Journey” at the bottom of this page!
Your habits influence your attitude, sleep, food cravings…and autoimmunity. Many of you that suspect you may have an autoimmune condition, or have been diagnosed with one, may in fact have two or more lurking within.
Have you noticed that when you eat pleasure-seeking foods such as sweets, alcohol, or caffeine (and for some, Chinese food), you want more of it shortly after you consume them? In an age of sugar-free, Keto, and every diet under the sun, where does real sugar stop and artificial sweeteners start?
Every restaurant table and coffee bar have these colorful, single-serving sized packets screaming at your taste buds, “Hey Sweet Tooth, I’m down here.” A laboratory accident turned popular over 130 years ago and the first super villain, saccharin, made its way into our food chain as a cheap and calorie-free alternative to cane sugar. Originally it was believed to be harmless, but over time, its question of safety rode a rollercoaster between science and industrial priorities.
Celebrities in the the cooking world have nothing good to say about these fake sweeteners. Colleague, close friend, and cookbook editor to Julia Child, Avis DeVoto wrote:
“Desserts, of which there is a fat section, are incredible—sweetened with saccharin [sic] and topped with imitation whipped cream! Fantastic! And I do believe a lot of people in this country eat just like that, stuffing themselves with faked materials in the fond belief that by substituting a chemical for God’s good food they can keep themselves slim while still eating hot breads and desserts and GUNK.”
To say the least, she was not a fan of this fake food and considered saccharin an empty pleasure.
When sugar became scarce during World War II, this diabetic substitute’s production ramped up. Between 1963 and 1967 artificially sweetened soft drinks nearly tripled their market share. By 1979, 44 million Americans used this sickly sweet, zero calorie alternative daily. As you can see by this chart, the rise has not slowed down, and is contributing to the obesity epidemic in America.
Chemical named by brand:
Acesulfame Potassium – Sunnett, Sweet One
Aspartame – Nutrasweet, Equal
Neotame – N/A
Saccharin – Sweet ‘N Low, Sweet Twin, Sugar Twin.
Sucralose – Splenda
Nutrition is among one of the contributing leaders to leaky gut syndrome. When foods are laden with pesticides, chemicals, artificial sweeteners and colors, combined with our nutrient deficient foods, our gut is constantly under attack and is no match for these “gut busting” toxins. If our food sources can not naturally support and feed the good bacteria, the bad bacteria begin to take over. Along with a nutrient dense diet, pharmaceutical grade supplementation has become paramount in therapeutic doses in order to restore our gut balance to tackle our autoimmune risk and conditions.
The sweet taste receptor (T1R3) is activated by artificial sweeteners. At high concentrations, many of the aforementioned chemical compounds were found to increase leaky gut and degrade cell regulation. This can lead to a myriad of issues including insulin resistance and diabetes. Primarily and first most, leaky gut leads to inflammation>symptoms>autoimmunity.
What about the reportedly safe “new age” sweeteners?
Chicory
Coconut sugar
Honey
Maple Syrup
Monk Fruit
Stevia
Although a monumental improvement in the form of nature vs lab, sugar in any form can spike your blood sugar and cause imbalances if consumed frequently (have you heard about devices which monitor your blood sugar?).
Grandma always said, “everything in moderation”. Unlike natural sugars including honey, maple syrup, and coconut sugar, stevia may be the lead in this cast of best choices for a sweet alternative, touting that it remains neutral in your bloodstream, and has a reduced calorie intake and low risk of cavities.
It has been reported that stevia could interfere with good bacteria in the gut, a strain on your kidneys or other organs, and/or possibly lower blood pressure, which could interfere with those on high blood pressure medications. There are always two sides to every story, and there isn’t enough research to conclude its downfalls. Just another reason to see an integrative or functional practitioner to get to the root cause of your tummy troubles.
The bottom line is: eat as close to the farm and whole food as possible. Teach your children at a young age how to read an ingredient label at the grocery store. It’s a fun and educational game that supports awareness around what is actually food, and what are lab experiments. Remember, you are what you eat. Bon Appetit!
It may be hard to believe, but brushing your teeth can help your joints. All dentists will tell you that your dental health is tied to your physical health, but how seriously do we really take that? Your mouth has its own microbiome, which is the mini ecosystem made up of bacteria and other small life forms, just like your gut and your skin. When any of your microbiomes are out of balance, there will be consequences.
Rheumatoid arthritis (RA) is an autoimmune disease, which is a type of disease where someone’s body attacks itself. In the case of RA, the body is attacking the joints, causing painful inflammation that limits range of motion and affects daily activities. Many people with RA find themselves unable to run, walk, lift things, or even use their hands without severe pain.
How Does RA Start?
In functional medicine, our goal is to discover the root cause of disease. What we’ve learned is that all autoimmune diseases require three things in order to develop:
Genes: Without the genes for an autoimmune condition, the disease cannot manifest. Genes are not a life sentence, though. We have some control over whether our genes are actually expressed or “stay asleep”. Just because you have the genes, doesn’t mean you’ll have the condition!
Leaky gut: The cells that make up our intestine lining are held together by tight junctions, which are important for keeping our partially-digested food from seeping out. Many factors, including gluten and NSAIDs such as Ibuprofen, cause these tight junctions to loosen and allow material to leak out, which causes inflammation in the body. Read more about the gut’s connection to RA here.
Last but not least, a trigger: Many things can trigger an autoimmune response, including viral or bacterial infections.
One specific type of bacterial infection has been tied to RA as a trigger. The bacteria is called Porphyromonas gingivalis and is also a common culprit behind periodontal disease, a common gum disease. In periodontal disease, an infection causes inflammation in the gums and can lead to symptoms such as:
Swollen, red, and tender gums
Bleeding gums
In more serious cases, tooth loss (periodontitis)
Gum Disease and RA
Have you ever wondered what plaque on your teeth actually is? Bacteria such as P. gingivalis produce a sticky film that can build up- and that becomes plaque! The bacteria in plaque create acids, which slowly break down tooth enamel. Not only does the yellowish film not look pretty, but it can lead to gum disease andrheumatoid arthritis. P. gingivalis causes nasty inflammation in the gums, as you can see in the picture above, so just imagine the inflammation it can cause in your joints!
It has become clear that periodontal disease and periodontitis are linked to RA, but recent research has been able to narrow down the link to P. gingivalis bacteria specifically.
In this study, mice that were infected with P. gingivalis bacteria either developed arthritis, or their already existing arthritis got worse. Another study found that the correlation between the antibody to P. gingivalis and RA was even stronger- in fact, two times stronger- than the correlation between smoking and RA. Smoking has been a known major risk factor for RA for many years, but now we know that periodontal disease caused by P. gingivalis bacteria is more than twice as likely to lead to RA. Do you believe the dentists now?
Your RA Might Have a “Friend”
For the most part, good dental hygiene can keep bad bacteria from running rampant. Brushing and flossing twice a day as well as regular visits to a dentist are important steps to take. One way that P. gingivalis can grow is if your mouth is too dry. Unfortunately, another autoimmune condition, Sjögren’s syndrome, specifically attacks the salivary glands and leaves the mouth very dry. Sjögren’s is therefore a risk factor for plaque buildup and periodontal disease. Given what we just learned about the connection between periodontal disease and RA, it should be no surprise that 21% of Sjögren’s patients have also been diagnosed with rheumatoid arthritis.
This is a common theme in our office: Many people who have been diagnosed with one autoimmune disease also develop another one or more. In fact, at the time someone is diagnosed with an autoimmune disease, there is a 50% chance that another one already exists. If the genes are there and the environment allows one disease to develop, then it is very likely that other autoimmune genes will be triggered.
At Dr. Autoimmune, we use a functional medicine approach to get to the root cause of complex conditions. Our structured program removes the guesswork and uses science-backed lab testing, diet change, and supplementation to get your body back on track. Using this method, we have an 85% success rate. If you’re interested in finding real solutions for your conditions, fill out the form below to get started!
Food sensitivities
